Journal Article: In class the question of how cartilage ages came up. Here is an abstract of a paper that looks at the age-related changes seen in the chondrocytes within articular cartilage (the thin layer of hyaline cartilage that covers the surface of bones at joints): "These changes most likely are the result of an age related decrease in the ability of chondrocytes to maintain and repair the tissue manifested by decreased mitotic and synthetic activity, decreased responsiveness to anabolic growth factors and synthesis of ... less functional link proteins".
These changes are considered to be directly related to the increase in osteoarthritis that is so typical of the aging process.
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